Epigenetics and Occupational Health

Epigenetics of Public Health

Center for Epigenetics, Johns Hopkins School of Medicine

Environmental Chemical Exposures and Human Epigenetics
Int. J. Epidemiol. (2012) 41 (1): 79-105

(PDF file)

The Social Environment and the Epigenome

Szyf M, McGowan P, Meaney MJ. - McGill University
Environ Mol Mutagen. 2008 Jan; 49(1):46-60.

University of Michigan - The Epigenetic Regulation Research Team

Epigenetic mechanisms are essential regulators of gene expression throughout life, and include methylation of DNA and methylation, acetylation, phosphorylation, ubiquitination and polyADP-ribosylation of histones. These covalent modifications regulate chromatin structure, chromatin remodeling, genome stability and DNA repair, with an ultimate impact on gene expression and cellular function (Richardson, 2007; Shukia et al., 2008). Epigenetic modifications are dynamic and susceptible to environmental influences. DNA methylation patterns must be replicated each time a cell divides, and the efficiency of this reaction depends on intracellular S-adenosylmethionine, S-adenosylhomocysteine, and DNA methyltransferase 1 levels (Richardson, 2007). Thus the replication of DNA methylation patterns is sensitive to dietary influences and xenobiotics that inhibit DNA methylation, such as genistein and bisphenol A (Baccarelli and Bollati, 2009). Hypermethylation of DNA sequences also occurs with aging, contributing to the development of malignancies (Cheung et al., 2009), and is likely environmentally sensitive. Histone modifications are sensitive to environmental agents through impacts on the histone deacetylases and acetylases or the intracellular pools of molecules required for the modifications, such as acetyl-CoA or S-adenosylmethionine. Epigenetic dysregulation may contribute to the development of many poorly understood human diseases, such as asthma (Miller and Ho, 2008), prematurity (Hofman et al., 2006), metabolic syndrome (Symonds et al., 2009) and neurodegenerative diseases such as Alzheimer's (Zawia et al., 2009), as well as cancers, lupus, and other diseases (Dolinoy and Jirtle, 2008).

Environmental epigenetics:
prospects for studying epigenetic mediation of exposure response relationships

Cortessis VK, Thomas DC, Levine AJ, Breton CV, Mack TM, Siegmund KD, Haile RW, Laird PW - Department of Preventive Medicine, Keck School of Medicine, University of Southern California

Alzheimer's disease and environmental exposure to lead:
the epidemiologic evidence and potential role of epigenetics

Bakulski KM, Rozek LS, Dolinoy DC, Paulson HL, Hu H - University of Michigan, School of Public Health, Department of Environmental Health Sciences

Environmental Epigenetics and Its Implication on Disease Risk and Health Outcomes

Dr. Shuk-Mei Ho, Division of Environmental Genetics and Molecular Toxicology
Department of Environmental Health, College of Medicine, University of Cincinnati

Prenatal environmental exposures, epigenetics, and disease

Frederica Perera, Julie Herbstman - Columbia Center for Children’s Environmental Health, Mailman School of Public Health, Columbia University (pdf file)

Impact of Direct Soil Exposures from Airborne Dust and Geophagy on Human Health

David Sing and Charles F Sing
Int J Environ Res Public Health. 2010 March; 7(3): 1205–1223

EPIGENETICS

The University of Utah Genetics Learning Centre

Epigenetic Influences and Disease

Danielle Simmons, Ph.D.

Stephen Baylin, M.D., - Epigenetics

Johns Hopkins Medicine Online Video

Center For Epigenetics

Johns Hopkins School of Medicine

Epigenetics: when the environment modifies the genes

Douglas Mental Health Institute

The McGill University and Génome Québec Innovation Centre

McGill University

Genetics, Epigenetics and Disease

The Royal Society, London

Prenatal environmental exposures, epigenetics, and disease

Perera F, Herbstman J.
Columbia Center for Children's Environmental Health, Mailman School of Public Health, Columbia University

Epigenetics: What Makes Us Who We Are? - Begin Before Birth

YouTube

Epigenetics and Environmental Diseases

(PDF file)

The Harvard/MGH Center on Genomics, Vulnerable Populations, and Health Disparities

Mongan Institute for Health Policy, Massachusetts General Hospital

Epigenomics in Environmental Health

Brock C. Christensen1, and Carmen J. Marsit - Front Genet. 2011; 2: 84

Environmental chemical exposures and human epigenetics

Lifang Hou et al - Feinberg School of Medicine, Northwestern University

11th Annual Koch Institute Symposium: Collaboration Between Transcriptional and Epigenetic Regulators

Richard Young, Whitehead Institute, MIT (video)

The Center for Ecogenetics and Environmental Health

Department of Environmental and Occupational Health Sciences, School of Public Health, University of Washington

The Institute of Environmental Medicine, NYU Langone Medical Center

"The theme of our Department’s research is to understand the environmental causes of disease by investigating which genes, epigenetic programs, and cell signaling pathways influence the processes of disease development. Our Department focuses on several important research areas, including early detection and prevention, health effects of metals and particulate matter, and susceptibility to environmental disease. We strive to build upon our mounting strength in epigenetics by including this as a focus in all aspects of our research."

Genetics in the Workplace - Implications for Occupational Safety and Health

NIOSH (PDF file)

EXPOSOME AND EXPOSOMICS

CDC

Environmental Epigenetics

Alentina Bollati and Andrea Baccarelli - enter of Molecular and Genetic Epidemiology Department of Environmental and Occupational Health Università degli Studi di Milano

Hazard identification and risk evaluation in the metal industry: the epigenetic challenge

Bertazzi PA, Bollati V, Bonzini M. - Dipartimento di Scienze Cliniche e di Comunità, Università degli Studi, Milano, Italy

Epigenetics in Pediatric Environmental Health

CEHN Research Conference - San Francisco, CA, May 30–June 1, 2012 (PDF file)

Study finds a possible biomarker of occupational exposure in firefighters

National Institute of Environmental Health Sciences

Epigenetics and the developmental origins of disease

Health & Environment - Paul Whaley, Editor

Epigenetics and environmental chemicals

A Baccarelli and V. Bollati - Curr Opin Pediatr. 2009 April; 21(2): 243–251

Epigenetics in metal carcinogenesis: Nickel, Arsenic, Chromium and Cadmium

Adriana Arita and Max Costa - Nelson Institute of Environmental Medicine, New York University School of Medicine (PDF file)

Reproductive and Developmental Hazard Management Guidance

American College of Occupational and Environmental Medicine

The Collaborative on Health and the Environment

Searchable Calendar of Events

Developmental origins of non-communicable disease: Implications for research and public health

Robert Barouki, Peter D Gluckman, Philippe Grandjean, Mark Hanson and Jerrold J Heindel - Environmental Health 2012, 11:42

Environmental Triggers and Epigenetic Deregulation in Autoimmune Disease

Biola M. Javierre - 2013, Discovery Medicine

Decoding Epigenetic Influences on Behavior and Mental Health

Environmental Health Perspectives • volume 120 | number 10 | October 2012 (PDF file)

Epigenetics mediate environment : gene effects on occupational sensitization

Pacheco KA. - Colorado School of Public Health, Aurora, Colorado, USA

Asthma: an epidemic caused by epigenetics?

D. Schwartz, University of Colorado

Epigenetics - Connecting Environment and Genotype to Phenotype and Disease

S.P. Barros and S. Offenbacher - J Dent Res. 2009 May; 88(5): 400–408

Genetic Susceptibility and the Setting of Occupational Health Standards

Paul Schulte and John Howard
National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention (PDF file)

Genetics and occupational safety and health

Karl T Kelsey - Occup Environ Med v.64(11); Nov 2007

More Chemicals Show Epigenetic Effects across Generations

Bob Weinhold - Environ Health Perspect. 2012 June; 120(6): a228.

Do epigenetic changes play a role in the development of chronic toxic encephalopathy?

Conference on Occupational Health - Mar. 2012

Environmental Toxicants, Epigenetics, and Cancer

Igor P. Pogribny and Ivan Rusyn (PDF file)

THE GHOST IN OUR GENES: LEGAL AND ETHICAL IMPLICATIONS OF EPIGENETICS

Mark A. Rothstein, Yu Cai, and Gary E. Marchant - Health Matrix Clevel. 2009 Winter; 19(1): 1–62.

Epigenetics Research, the Top 20 Institutions

ScienceWatch.com

Epigenetics, Environment, and Genes

January 01, 2013 by Apple Academic Press - 250 Pages

 


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